BURDEN OF DISEASE ATTRIBUTABLE TO RISK FACTORS IN BRAZIL: AN ANALYSIS OF NATIONAL AND SUBNATIONAL ESTIMATES FROM THE 2019 GLOBAL BURDEN OF DISEASE STUDY

Abstract INTRODUCTION: Monitoring trends in risk factors (RFs) and the burden of diseases attributable to exposure to RFs is an important measure to identify public health advances and current inadequate efforts.Objective: Analyze the global burden of disease attributable to exposure RFs in Brazil, and its changes from 1990 to 2019, according to th

The aim of this short review is to present the progress made in wildland fire modelling during the last 50 years and the intellectual track followed by wildland fires models, from fully empirical models in the 60s, to semi-empirical ones in Giftware the 70s, to fully physical models at the end of the 90s.During the last period, the large diffusion

Summary: Background: Pancreatic ductal adenocarcinoma (PDAC) is a tumour entity with unmet medical need.To assess the therapeutic potential of oncolytic virotherapy (OVT) against PDAC, different oncolytic viruses (OVs) are currently investigated in clinical trials.However, systematic comparisons of these different OVs in terms of efficacy against P

Abstract Cancer cells can evade immune responses by exploiting inhibitory immune checkpoints.Immune checkpoint inhibitor (ICI) therapies based on anti-CTLA-4 and anti-PD-1/PD-L1 antibodies have been extensively explored over the recent years to unleash otherwise compromised anti-cancer immune responses.However, it is also well established that immu